Sustained plasma TNF-α and HIV-1 load despite resolution of other parameters of immune activation during treatment of tuberculosis in Africans
Identifieur interne : 001207 ( Main/Exploration ); précédent : 001206; suivant : 001208Sustained plasma TNF-α and HIV-1 load despite resolution of other parameters of immune activation during treatment of tuberculosis in Africans
Auteurs : S. D. Lawn [États-Unis, Royaume-Uni] ; R. J. Shattock [Royaume-Uni] ; J. W. Acheampong [Ghana] ; R. B. Lal [États-Unis] ; T. M. Folks [États-Unis] ; G. E. Griffin [Royaume-Uni] ; S. T. Butera [États-Unis]Source :
- AIDS : (London) [ 0269-9370 ] ; 1999.
Descripteurs français
- KwdFr :
- Antigènes HLA-DR (immunologie), Antituberculeux (usage thérapeutique), Charge virale, Facteur de nécrose tumorale alpha (métabolisme), Ghana, Humains, Infections opportunistes liées au SIDA (immunologie), Infections opportunistes liées au SIDA (traitement médicamenteux), Infections opportunistes liées au SIDA (virologie), Tuberculose (), Tuberculose (immunologie), Tuberculose (traitement médicamenteux), Tuberculose (virologie), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (isolement et purification).
- MESH :
- immunologie : Antigènes HLA-DR, Infections opportunistes liées au SIDA, Tuberculose.
- isolement et purification : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- métabolisme : Facteur de nécrose tumorale alpha.
- traitement médicamenteux : Infections opportunistes liées au SIDA, Tuberculose.
- usage thérapeutique : Antituberculeux.
- virologie : Infections opportunistes liées au SIDA, Tuberculose.
- Pascal (Inist)
- Charge virale, Ghana, Humains, SIDA, Tuberculose, Virus HIV1, Infection opportuniste, Tuberculose, Complication, Chimiothérapie, Traitement, Plasma sanguin, Facteur nécrose tumorale α, Efficacité traitement, Immunorestauration, Exploration immunologique, Charge virale, Antituberculeux, Antibactérien, Homme.
- Wicri :
English descriptors
- KwdEn :
- AIDS, AIDS-Related Opportunistic Infections (drug therapy), AIDS-Related Opportunistic Infections (immunology), AIDS-Related Opportunistic Infections (virology), Antibacterial agent, Antitubercular Agents (therapeutic use), Antituberculous agent, Blood plasma, Chemotherapy, Complication, Ghana, HIV-1 (isolation & purification), HIV-1 virus, HLA-DR Antigens (immunology), Human, Humans, Immune reconstitution, Immunological investigation, Opportunistic infection, Treatment, Treatment efficiency, Tuberculosis, Tuberculosis (complications), Tuberculosis (drug therapy), Tuberculosis (immunology), Tuberculosis (virology), Tumor Necrosis Factor-alpha (metabolism), Tumor necrosis factor α, Viral Load, Viral load.
- MESH :
- chemical , immunology : HLA-DR Antigens.
- chemical , metabolism : Tumor Necrosis Factor-alpha.
- chemical , therapeutic use : Antitubercular Agents.
- geographic : Ghana.
- complications : Tuberculosis.
- drug therapy : AIDS-Related Opportunistic Infections, Tuberculosis.
- immunology : AIDS-Related Opportunistic Infections, Tuberculosis.
- isolation & purification : HIV-1.
- virology : AIDS-Related Opportunistic Infections, Tuberculosis.
- Humans, Viral Load.
Abstract
Objective: To determine the impact of treatment of tuberculosis on plasma HIV-1 load in African subjects and to correlate viral load with response to treatment and changes in immune activation. Design: Clinical and microbiological responses, immune activation parameters and plasma HIV-1 load were determined in 20 patients with pulmonary tuberculosis and HIV-1 coinfection in Ghana, West Africa during the first 3 months of anti-tuberculosis treatment. Methods: Plasma HIV-1 load and markers of immune activation were determined by commercially available assays. Human leukocyte antigen (HLA)-DR incorporation into the HIV-1 envelope was measured by using an immunomagnetic capture technique. Results: Treatment of tuberculosis resulted in significant improvements in weight and haemoglobin, a high sputum smear conversion rate and marked reductions in mean plasma tumour necrosis factor (TNF) receptor-1, interleukin-6 and C-reactive protein. Furthermore, incorporation of host HLA-DR into the HIV-1 envelope decreased; this also suggested a reduction in immune activation of the cells supporting viral replication. However, of importance with regard to AIDS pathogenesis, neither mean plasma TNF-α nor HIV-1 load decreased significantly. Conclusions: The failure of HIV-1 plasma load to decline significantly during the initial months of anti-tuberculosis treatment is associated with high, sustained systemic levels of TNF-α. The dissociation between the sustained levels of plasma TNF-α and the major reductions in other, diverse immune activation parameters may represent dysregulation of cytokine production in these African patients.
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Objective: To determine the impact of treatment of tuberculosis on plasma HIV-1 load in African subjects and to correlate viral load with response to treatment and changes in immune activation. Design: Clinical and microbiological responses, immune activation parameters and plasma HIV-1 load were determined in 20 patients with pulmonary tuberculosis and HIV-1 coinfection in Ghana, West Africa during the first 3 months of anti-tuberculosis treatment. Methods: Plasma HIV-1 load and markers of immune activation were determined by commercially available assays. Human leukocyte antigen (HLA)-DR incorporation into the HIV-1 envelope was measured by using an immunomagnetic capture technique. Results: Treatment of tuberculosis resulted in significant improvements in weight and haemoglobin, a high sputum smear conversion rate and marked reductions in mean plasma tumour necrosis factor (TNF) receptor-1, interleukin-6 and C-reactive protein. Furthermore, incorporation of host HLA-DR into the HIV-1 envelope decreased; this also suggested a reduction in immune activation of the cells supporting viral replication. However, of importance with regard to AIDS pathogenesis, neither mean plasma TNF-α nor HIV-1 load decreased significantly. Conclusions: The failure of HIV-1 plasma load to decline significantly during the initial months of anti-tuberculosis treatment is associated with high, sustained systemic levels of TNF-α. The dissociation between the sustained levels of plasma TNF-α and the major reductions in other, diverse immune activation parameters may represent dysregulation of cytokine production in these African patients.</div>
</front>
</TEI>
<affiliations><list><country><li>Ghana</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Géorgie (États-Unis)</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Lawn, S D" sort="Lawn, S D" uniqKey="Lawn S" first="S. D." last="Lawn">S. D. Lawn</name>
</region>
<name sortKey="Butera, S T" sort="Butera, S T" uniqKey="Butera S" first="S. T." last="Butera">S. T. Butera</name>
<name sortKey="Folks, T M" sort="Folks, T M" uniqKey="Folks T" first="T. M." last="Folks">T. M. Folks</name>
<name sortKey="Lal, R B" sort="Lal, R B" uniqKey="Lal R" first="R. B." last="Lal">R. B. Lal</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lawn, S D" sort="Lawn, S D" uniqKey="Lawn S" first="S. D." last="Lawn">S. D. Lawn</name>
</region>
<name sortKey="Griffin, G E" sort="Griffin, G E" uniqKey="Griffin G" first="G. E." last="Griffin">G. E. Griffin</name>
<name sortKey="Shattock, R J" sort="Shattock, R J" uniqKey="Shattock R" first="R. J." last="Shattock">R. J. Shattock</name>
</country>
<country name="Ghana"><noRegion><name sortKey="Acheampong, J W" sort="Acheampong, J W" uniqKey="Acheampong J" first="J. W." last="Acheampong">J. W. Acheampong</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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